Gene deficiencies that can cause obesity > WEB 중요웹사이트연결

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Gene deficiencies that can cause obesity include disruptions in the leptin-melanocortin pathway, such as mutations in the LEP, LEPR, MC4R, and POMC genes. Other genes implicated are PCSK1, which affects the processing of several hormones, and SH2B1, which is involved in leptin and insulin signaling.
Leptin-Melanocortin Pathway Genes
LEP (Leptin): Deficiency in the leptin hormone can lead to hyperphagia and obesity.


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