Atorvastatin 아토르바스타틴(--콜레스테롤의 합성을 억제하여 고지혈증을 치료한다 10, 20 or 40 > 건강/ 약품 Drug / 보조 약품

• 목록
• 게시판 리스트 옵션
  • 수정
  • 삭제

아토르바스타틴(atorvastatin) --콜레스테롤의 합성을 억제하여 고지혈증을 치료한다 10, 20 or 40
[Website를 Copy하여 인터넷에서 보십시요]
https://en.wikipedia.org/wiki/Atorvastatin
https://ko.wikipedia.org/wiki/%EC%95%84%ED%86%A0%EB%B0%94%EC%8A%A4%ED%83%80%ED%8B%B4
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
아토바스타틴 - 위키백과, 우리 모두의 백과사전

아토르바스타틴(atorvastatin)

아토르바스타틴은 스타틴 계열의 약물로, 콜레스테롤의 합성을 억제하여 고지혈증을 치료한다. 고지혈증. 환자의 콜레스테롤 감소를 위한 식이요법 보조 및 심장혈관 질환 ...
------------------------------------------------------------------------------------------------------------------------------------------------------------------
아토바스타틴(Atorvastatin)은 리피토(Lipitor)라는 상품명으로 팔리는 약의 주성분이다. 화이자(Pfizer)에서 아토바스타틴을 칼슘염 형태로 만들어 제품화한 것이 리피토이다.[1] HMG CoA 환원효소(HMG CoA reductase)를 억제하기 때문에 HMG CoA 환원효소 억제제라고 한다. HMG CoA 환원효소 억제제는 주로 ~스타틴(statin)으로 끝나는 이름을 가지기 때문에 보통 '스타틴계 약물(statins)'라고 분류한다.[2] 대한민국에서는 한국화이자제약에서 수입하고, 한국화이자제약과 제일약품이 공동 판매한다.[3] 2014년 리피토의 병원외처방액은 979억여 원으로[4] 2014년 국내 원외처방 시장에서 2위를 기록했다.[5] 10mg, 20mg, 40mg, 80mg 제품이 있다.[6]

효능
아토바스타틴은 비정상적으로 상승된 콜레스테롤 수치를 낮추기 때문에 이상지질혈증(Dyslipidemias, 고지혈증)의 치료와 심혈관계 질환의 예방에 쓰인다.[7] 아토바스타틴을 포함한 스타틴계 약물은 이미 상승해 있는 콜레스테롤 수치를 낮춘다. 이는 콜레스테롤 합성의 첫 번째 단계를 매개하는 효소의 작용을 억제하기 때문이다. 따라서 스타틴계 약물은 LDL 콜레스테롤이 상승한 환자에게 주로 1차적으로 사용하는 약물이다.[8]

작용기전(메커니즘)
아토바스타틴의 작용기전은 LDL 수용체를 과발현시켜 혈중 콜레스테롤을 간 내부로 유입시키는 것인데, 이는 HMG CoA 환원효소(간 내부 콜레스테롤 합성 속도조절효소)를 억제함으로써 간 내부 콜레스테롤 수치가 낮아지며 발현된다.

HMG CoA 환원효소 억제제 (스타틴계, Statins)
이 부분의 본문은 스타틴입니다.
HMG CoA 환원효소(HMG CoA reductase)를 억제하는 약물을 HMG CoA 환원효소 억제제(HMG CoA reductase inhibitor)라고 부른다. 보통 스타틴계(statins) 약물이라고 알려져있다.[2] 이 계열 약물의 이름이 주로 "스타틴"으로 끝나기 때문이다. HMG CoA 환원효소 억제제로는 아토바스타틴(Atorvastatin) 외에도 피타바스타틴(Pitavastatin), 로바스타틴(Lovastatin), 심바스타틴(Simvastatin), 프라바스타틴(Pravastatin), 플루바스타틴(Fluvastatin), 로슈바스타틴(Rosuvastatin) 등이 있다.

===========================================================================================================
Atorvastatin
Pronunciation
Generic Name: atorvastatin (a TOR va sta tin)
Brand Names: Lipitor

Overview
Side Effects
Dosage
Professional
Need to Know
Interactions
More
What is atorvastatin?

Atorvastatin is in a group of drugs called HMG CoA reductase inhibitors, or "statins." Atorvastatin reduces levels of "bad" cholesterol (low-density lipoprotein, or LDL) and triglycerides in the blood, while increasing levels of "good" cholesterol (high-density lipoprotein, or HDL).
Atorvastatin is used to treat high cholesterol, and to lower the risk of stroke, heart attack, or other heart complications in people with type 2 diabetes, coronary heart disease, or other risk factors.
Atorvastatin is used in adults and children who are at least 10 years old.
Important information
You should not take atorvastatin if you are pregnant or breast-feeding, or if you have liver disease.
Stop taking this medication and tell your doctor right away if you become pregnant.
Serious drug interactions can occur when certain medicines are used together with atorvastatin. Tell each of your healthcare providers about all medicines you use now, and any medicine you start or stop using.


Slideshow
PCSK9 Inhibitors: A New Class of Cholesterol Busters
In rare cases, atorvastatin can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, and dark colored urine.
Avoid eating foods that are high in fat or cholesterol. Atorvastatin will not be as effective in lowering your cholesterol if you do not follow a cholesterol-lowering diet plan.
Atorvastatin is only part of a complete program of treatment that also includes diet, exercise, and weight control. Follow your diet, medication, and exercise routines very closely.
Before taking this medicine
You should not use atorvastatin if you are allergic to it, or if you have:
liver disease; or
if you are pregnant or breast-feeding.
Atorvastatin can harm an unborn baby or cause birth defects. Do not use if you are pregnant. Stop taking this medicine and tell your doctor right away if you become pregnant. Use effective birth control to prevent pregnancy while you are taking this medicine.
Atorvastatin may pass into breast milk and could harm a nursing baby. Do not breast-feed while you are taking thsi medicine.
To make sure this medicine is safe for you, tell your doctor if you have ever had:
liver problems;
muscle pain or weakness;
kidney disease;
diabetes;
a thyroid disorder; or
if you drink more than 2 alcoholic beverages daily.
Atorvastatin can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. This condition may be more likely to occur in older adults and in people who have kidney disease or poorly controlled hypothyroidism (underactive thyroid).
Atorvastatin is not approved for use by anyone younger than 10 years old.
How should I take atorvastatin?
Take atorvastatin exactly as prescribed by your doctor. Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not use this medicine in larger or smaller amounts or for longer than recommended.
Atorvastatin is usually taken once a day, with or without food. Take the medicine at the same time each day.
Do not break or crush a tablet before taking it.
You may need to stop using this medicine for a short time if you have:
uncontrolled seizures;
an electrolyte imbalance (such as high or low potassium levels in your blood);
severely low blood pressure;
a severe infection or illness; or
surgery or a medical emergency.

It may take up to 2 weeks before your cholesterol levels improve, and you may need frequent blood test. You may not notice any change in your symptoms, but keep using the medication as directed. Your blood work will help your doctor determine how long to treat you with atorvastatin.
Atorvastatin is only part of a complete treatment program that may also include diet, exercise, and weight control. Follow your doctor's instructions very closely.
Store at room temperature away from moisture, heat, and light.
See also: Dosage Information (in more detail)
What happens if I miss a dose?
Take the missed dose as soon as you remember. Skip the missed dose if your next dose is less than 12 hours away. Do not take extra medicine to make up the missed dose.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What should I avoid while taking atorvastatin?
Avoid eating foods that are high in fat or cholesterol. Atorvastatin will not be as effective in lowering your cholesterol if you do not follow a cholesterol-lowering diet plan.
Avoid drinking alcohol. It can raise triglyceride levels and may increase your risk of liver damage.
Grapefruit and grapefruit juice may interact with atorvastatin and lead to potentially dangerous effects. Avoid drinking more than 1 liter of grapefruit juice while taking this medicine.
Atorvastatin side effects
Get emergency medical help if you have signs of an allergic reaction to atorvastatin: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
In rare cases, atorvastatin can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, and dark colored urine.
Also call your doctor at once if you have:
pain or burning when you urinate;
liver problems - upper stomach pain, weakness, tired feeling, loss of appetite, dark urine, jaundice (yellowing of the skin or eyes); or
kidney problems - little or no urinating, swelling in your feet or ankles, feeling tired or short of breath.
Common atorvastatin side effects may include:
joint pain;
stuffy nose, sore throat;
diarrhea; or
pain in your arms or legs.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)